Efficient Triplet鈥揟riplet Annihilation-Based Upconversion for Nanoparticle Phototargeting

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• 作者：Weiping Wang ; Qian Liu ; Changyou Zhan ; Aoune Barhoumi ; Tianshe Yang ; Ryan G. Wylie ; Patrick A. Armstrong ; Daniel S. Kohane
• 刊名：Nano Letters
• 出版年：2015
• 出版时间：October 14, 2015
• 年：2015
• 卷：15
• 期：10
• 页码：6332-6338
• 全文大小：513K
• ISSN：1530-6992

文摘

High-efficiency upconverted light would be a desirable stimulus for triggered drug delivery. Here we present a general strategy to achieve photoreactions based on triplet鈥搕riplet annihilation upconversion (TTA-UC) and F枚rster resonance energy transfer (FRET). We designed PLA鈥揚EG micellar nanoparticles containing in their cores hydrophobic photosensitizer and annihilator molecules which, when stimulated with green light, would undergo TTA-UC. The upconverted energy was then transferred by FRET to a hydrophobic photocleavable group (DEACM), also in the core. The DEACM was bonded to (and thus inactivated) the cell-binding peptide cyclo-(RGDfK), which was bound to the PLA鈥揚EG chain. Cleavage of DEACM by FRET reactivated the PLA鈥揚EG-bound peptide and allowed it to move from the particle core to the surface. TTA-UC followed by FRET allowed photocontrolled binding of cell adhesion with green light LED irradiation at low irradiance for short periods. These are attractive properties in phototriggered systems.