Synthesis of Polyheteroaromatic Compounds via Rhodium-Catalyzed Multiple C鈥揌 Bond Activation and Oxidative Annulation

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• 作者：Shiyong Peng ; Suna Liu ; Sai Zhang ; Shengyu Cao ; Jiangtao Sun
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：October 16, 2015
• 年：2015
• 卷：17
• 期：20
• 页码：5032-5035
• 全文大小：414K
• ISSN：1523-7052

文摘

Polyheteroaromatic compounds are potential optoelectronic conjugated materials due to their electro- and photochemical properties. Transition-metal-catalyzed multiple C鈥揌 activation and sequential oxidative annulation allows rapidly assembling of those compounds from readily available starting materials. A rhodium-catalyzed cascade oxidative annulation of 尾-enamino esters or 4-aminocoumarins with internal alkynes is described to access those compounds, featuring multiple C鈥揌/N鈥揌 bond cleavages and sequential C鈥揅/C鈥揘 bond formations in one pot.