An Organocatalysis Based Carbocyclic Spiroindoline Synthesis Enables Facile Structure鈥揂ctivity Relationship (SAR) Study at C2 Position

详细信息    查看全文

• 作者：Yongsheng Zheng ; Jacob Cleaveland ; David Richardson ; Yu Yuan
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：September 4, 2015
• 年：2015
• 卷：17
• 期：17
• 页码：4240-4243
• 全文大小：344K
• ISSN：1523-7052

文摘

An asymmetric synthesis of carbocyclic spiroindoline by sequential Michael reaction and [3 + 2]-cycloaddition is described. This protocol demonstrates excellent enantio- and diastereoselectivity with broad functional group tolerance. A diverse range of spiroindolines were prepared by this approach, and the products served as ideal substrates for C2 derivatization.