Bisacremines E鈥揋, Three Polycyclic Dimeric Acremines Produced by Acremonium persicinum SC0105

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• 作者：Ping Wu ; Jinghua Xue ; Lei Yao ; Liangxiong Xu ; Hanxiang Li ; Xiaoyi Wei
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：October 2, 2015
• 年：2015
• 卷：17
• 期：19
• 页码：4922-4925
• 全文大小：276K
• ISSN：1523-7052

文摘

Three dimeric acremines, bisacremines E鈥揋 (1鈥?b>3), with an unusual carbon skeleton were isolated from cultures of the soil-derived fungus Acremonium persicinum SC0105. Their structures were elucidated by spectroscopic analysis, X-ray diffraction, and ECD/TDDFT computations. Compound 3 exhibited inhibitory effects on the production of TNF-伪, IL-6, and NO in LPS-stimulated macrophages. A biogenetic pathway with a [4 + 2] cycloaddition as the key reaction is proposed for 1鈥?b>3.