Catalytic Asymmetric [3 + 2] Cyclization Reactions of 3-Isothiocyanato Oxindoles and Alkynyl Ketones Via an in Situ Generated Magnesium Catalyst

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• 作者：Linqing Wang ; Dongxu Yang ; Dan Li ; Xihong Liu ; Qian Zhao ; Ranran Zhu ; Bangzhi Zhang ; Rui Wang
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：September 4, 2015
• 年：2015
• 卷：17
• 期：17
• 页码：4260-4263
• 全文大小：365K
• ISSN：1523-7052

文摘

A highly enantioselective formal [3 + 2] cycloaddition reaction between 3-isothiocyanato oxindoles and alkynyl ketones is reported for the first time. An oxazoline鈥揙H type chiral ligand derived from o-hydroxy-phenylacetic acid is employed to generate an effective magnesium catalyst in the current cyclization reaction and give serials of chiral spirooxindoles with good chemical yields and enantioselectivities.