Pericoannosin A, a Polyketide Synthase鈥揘onribosomal Peptide Synthetase Hybrid Metabolite with New Carbon Skeleton from the Endophytic Fungus Periconia sp.

详细信息    查看全文

• 作者：Dewu Zhang ; Xiaoyu Tao ; Ridao Chen ; Jimei Liu ; Li Li ; Xiaomei Fang ; Liyan Yu ; Jungui Dai
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：September 4, 2015
• 年：2015
• 卷：17
• 期：17
• 页码：4304-4307
• 全文大小：288K
• ISSN：1523-7052

文摘

Four new polyketide synthase鈥搉onribosomal peptide synthetase (PKS鈥揘RPS) hybrid metabolites, pericoannosin A (1), with an unusual hexahydro-1H-isochromen-5-isobutylpyrrolidin-2-one skeleton, and three cytochalasans, periconiasins D鈥揊 (2鈥?b>4), were isolated from the endophytic fungus Periconia sp. F-31. Their structures and absolute configurations were elucidated through extensive spectroscopic analyses, calculated ECD, and single-crystal X-ray diffraction (Cu K伪). A possible biogenetic pathway is proposed. Compounds 1 and 4 showed anti-HIV activity with IC₅₀s of 69.6 and 29.2 渭M, respectively.