A Single Picture Explains Diversity of Hyperthermia Response of Magnetic Nanoparticles

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• 作者：Ivan Conde-Leboran ; Daniel Baldomir ; Carlos Martinez-Boubeta ; Oksana Chubykalo-Fesenko ; Mar铆a del Puerto Morales ; Gorka Salas ; David Cabrera ; Julio Camarero ; Francisco J. Teran ; David Serantes
• 刊名：Journal of Physical Chemistry C
• 出版年：2015
• 出版时间：July 9, 2015
• 年：2015
• 卷：119
• 期：27
• 页码：15698-15706
• 全文大小：441K
• ISSN：1932-7455

文摘

Progress in the design of nanoscale magnets for localized hyperthermia cancer therapy has been largely driven by trial-and-error approaches, for instance, by changing of the stoichiometry composition, size, and shape of the magnetic entities. So far, widely different and often conflicting heat dissipation results have been reported, particularly as a function of the nanoparticle concentration. Thus, achieving hyperthermia-efficient magnetic ferrofluids remains an outstanding challenge. Here we demonstrate that diverging heat-dissipation patterns found in the literature can be actually described by a single picture accounting for both the intrinsic magnetic features of the particles (anisotropy, magnetization) and experimental conditions (concentration, magnetic field). Importantly, this general magnetic-hyperthermia scenario also predicts a novel non-monotonic concentration dependence with optimum heating features, which we experimentally confirmed in iron oxide nanoparticle ferrofluids by fine-tuning the particle size. Overall, our approach implies a magnetic hyperthermia trilemma that may constitute a simple strategy for development of magnetic nanomaterials for optimal hyperthermia efficiency.