Uniform PEGylated PLGA Microcapsules with Embedded Fe3O4 Nanoparticles for US/MR Dual-Modality Imaging

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• 作者：Sijia Xu ; Fei Yang ; Xiao Zhou ; Yaping Zhuang ; Baoxia Liu ; Yang Mu ; Xing Wang ; Hong Shen ; Guang Zhi ; Decheng Wu
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：September 16, 2015
• 年：2015
• 卷：7
• 期：36
• 页码：20460-20468
• 全文大小：556K
• ISSN：1944-8252

文摘

Well-designed agents for enhanced multimodal imaging have attracted great interests in recent years. In this work, we adopted a premix membrane emulsification (PME) method to prepare uniform PEGylated poly(lactic-co-glycolic acid) (PLGA) microcapsules (MCs) with superparamagnetic Fe₃O₄ nanoparticles (NPs) embedded in the shell (Fe₃O₄@PEG鈥揚LGA MCs) for ultrasound (US)/magnetic resonance (MR) bimodal imaging. Compared to Fe₃O₄@PLGA MCs without PEGylation, Fe₃O₄@PEG鈥揚LGA MCs could more stably and homogeneously disperse in physiological solutions. In vitro and in vivo trials demonstrated that Fe₃O₄@PEG鈥揚LGA MCs (鈭?.7 渭m) with very narrow size distribution (PDI = 0.03) could function as efficient dual-modality contrast agents to simultaneously enhance US and MR imaging performance greatly. In vitro cell toxicity and careful histological examinations illustrated no appreciable cytotoxicity and embolism of Fe₃O₄@PEG鈥揚LGA MCs to mice even at high dose. The uniform composite MCs developed here can act as clinical bimodal contrast agents to improve hybrid US/MR imaging contrast, which is promising for accurate diagnosis and real-time monitoring of difficult and complicated diseases.