Diethylene Glycol Serving as Ethyne Equivalent: A Sustainable Approach toward 2,3-Disubstituted Furan

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• 作者：Jin-Tao Yu ; Bo Shi ; Haibo Peng ; Song Sun ; Haoke Chu ; Yan Jiang ; Jiang Cheng
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：August 7, 2015
• 年：2015
• 卷：17
• 期：15
• 页码：3643-3645
• 全文大小：296K
• ISSN：1523-7052

文摘

In the presence of tert-butyl peroxide (TBHP), the copper-catalyzed annulation of 1,3-dicarbonyl compound with diethylene glycol was developed leading to 2,3-disubstituted furan. Diethylene glycol serves as a cheap and environmentally friendly equivalent of ethyne, with the release of H₂O and alcohol as clean wastes. The procedure involves a sequential O- and C- functionalization of 尾-ketoester by diethylene glycol.