纬-Carbon Activation through N-Heterocyclic Carbene/Br酶nsted Acids Cooperative Catalysis: A Highly Enantioselective Route to 未-Lactams

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• 作者：Yonglong Xiao ; Jinxin Wang ; Wenjing Xia ; Shuangjie Shu ; Shenchao Jiao ; Yu Zhou ; Hong Liu
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：August 7, 2015
• 年：2015
• 卷：17
• 期：15
• 页码：3850-3853
• 全文大小：364K
• ISSN：1523-7052

文摘

A 纬-carbon activation method that operates through N-heterocyclic carbene/Br酶nsted acid cooperative catalysis for highly enantioselective synthesis of 未-lactams is reported. The protocol allows the challenging remote 纬-carbon control of regioselectivity and enantioselectivity through introduction of an appropriate 纬-leaving group in the enals. The reaction offers good yields and excellent enantioselectivities, and the resulting cyclic products can be easily converted into high-value drug-like derivatives.