Iodine(III)-Mediated Oxy-fluorination of Alkenyl Oximes: An Easy Path to Monofluoromethyl-Substituted Isoxazolines

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• 作者：Weidong Kong ; Quanping Guo ; Zhaoqing Xu ; Guoqiang Wang ; Xianxing Jiang ; Rui Wang
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：August 7, 2015
• 年：2015
• 卷：17
• 期：15
• 页码：3686-3689
• 全文大小：374K
• ISSN：1523-7052

文摘

A highly regioselective intramolecular oxy-fluorination of alkenyl oximes was achieved. This new transformation represents an efficient method for the preparation of monofluoromethyl-substituted isoxazolines. The synthetic application of the oxy-fluorination product was demonstrated by a one-step synthesis of monofluoromethyl-substituted 尾-hydroxyl ketone derivatives.