Palladium-Catalyzed Monofluoromethylation of Arylboronic Esters with Fluoromethyl Iodide

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• 作者：Jingyu Hu ; Bing Gao ; Lingchun Li ; Chuanfa Ni ; Jinbo Hu
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：June 19, 2015
• 年：2015
• 卷：17
• 期：12
• 页码：3086-3089
• 全文大小：328K
• ISSN：1523-7052

文摘

The first palladium-catalyzed direct monofluoromethylation of arylboronic esters to produce monofluoromethyl arenes is reported. The reaction is typically carried out at room temperature within 4 h and has a good functional group tolerance. The monofluoromethylating agent, CH₂FI, was readily prepared via a halogen-exchange process.