Highly Rigid Labdane-Type Diterpenoids from a Chinese Liverwort and Light-Driven Structure Diversification

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• 作者：Jinchuan Zhou ; Jiaozhen Zhang ; Aixia Cheng ; Yuanxin Xiong ; Lei Liu ; Hongxiang Lou
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：July 17, 2015
• 年：2015
• 卷：17
• 期：14
• 页码：3560-3563
• 全文大小：279K
• ISSN：1523-7052

文摘

Two unprecedented labdane-type diterpenoids haplomintrins A (1) and B (2) with six rings system were isolated from a Chinese liverwort Haplomitrium mnioides. Light-driven reaction of homologous haplomitrenonolides C (6), A (4), and D (3) afforded haplomintrins A鈥揅 (1, 2, and 7), respectively, while 4 was converted to more complex congeners haplomintrins D鈥揋 (8鈥?b>11) through intramolecular cyclization. Formation of 1 and 2 from compounds 6 and 4, respectively, helps us to postulate that a photochemical reaction is involved in the biosynthetic pathway. These structure features can be used as molecular markers of H. mnioides, and their allelopathic effects are also preliminarily tested.