Nanoparticle-Stabilized Capsules for the Treatment of Bacterial Biofilms

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• 作者：Bradley Duncan ; Xiaoning Li ; Ryan F. Landis ; Sung Tae Kim ; Akash Gupta ; Li-Sheng Wang ; Rajesh Ramanathan ; Rui Tang ; Jeffrey A. Boerth ; Vincent M. Rotello
• 刊名：ACS Nano
• 出版年：2015
• 出版时间：August 25, 2015
• 年：2015
• 卷：9
• 期：8
• 页码：7775-7782
• 全文大小：598K
• ISSN：1936-086X

文摘

Bacterial biofilms are widely associated with persistent infections. High resistance to conventional antibiotics and prevalent virulence makes eliminating these bacterial communities challenging therapeutic targets. We describe here the fabrication of a nanoparticle-stabilized capsule with a multicomponent core for the treatment of biofilms. The peppermint oil and cinnamaldehyde combination that comprises the core of the capsules act as potent antimicrobial agents. An in situ reaction at the oil/water interface between the nanoparticles and cinnamaldehyde structurally augments the capsules to efficiently deliver the essential oil payloads, effectively eradicating biofilms of clinically isolated pathogenic bacteria strains. In contrast to their antimicrobial action, the capsules selectively promoted fibroblast proliferation in a mixed bacteria/mammalian cell system making them promising for wound healing applications.