First-Principles Investigation of Nanopore Sequencing Using Variable Voltage Bias on Graphene-Based Nanoribbons

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• 作者：Hannah L. McFarland ; Towfiq Ahmed ; Jian-Xin Zhu ; Alexander V. Balatsky ; Jason T. Haraldsen
• 刊名：The Journal of Physical Chemistry Letters
• 出版年：2015
• 出版时间：July 2, 2015
• 年：2015
• 卷：6
• 期：13
• 页码：2616-2621
• 全文大小：426K
• ISSN：1948-7185

文摘

In this study, we examine the mechanism of nanopore-based DNA sequencing using a voltage bias across a graphene nanoribbon. Using density function theory and a nonequilibrium Green鈥檚 function approach, we determine the transmission spectra and current profile for adenine, guanine, cytosine, thymine, and uracil as a function of bias voltage in an energy minimized configuration. Utilizing the transmission current, we provide a general methodology for the development of a three nanopore graphene-based device that can be used to distinguish between the various nucleobases for DNA/RNA sequencing. From our analysis, we deduce that it is possible to use different transverse currents across a multinanopore device to differentiate between nucleobases using various voltages of 0.5, 1.3, and 1.6 V. Overall, our goal is to improve nanopore design to further DNA/RNA nucleobase sequencing and biomolecule identification techniques.