Magnetic Hyperthermia Ablation of Tumors Using Injectable Fe3O4/Calcium Phosphate Cement

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• 作者：Chunyan Xu ; Yuanyi Zheng ; Wei Gao ; Jinshun Xu ; Guoqing Zuo ; Yu Chen ; Minzhu Zhao ; Jianbo Li ; Jinlin Song ; Nan Zhang ; Zhigang Wang ; Hongyun Zhao ; Zhechuan Mei
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：July 1, 2015
• 年：2015
• 卷：7
• 期：25
• 页码：13866-13875
• ISSN：1944-8252

文摘

In this work, we have developed an injectable and biodegradable material using CPC containing Fe₃O₄ nanoparticles for minimally invasive and efficiently magnetic hyperthermia ablation of tumors. When exposed to an alternating magnetic field, the MCPC could quickly generate heat. The temperature of PBS and the excised bovine liver increased with the MCPC weight, iron content, and time. The ablated liver tissue volume for 0.36 g of 10% MCPC was 0.2 卤 0.03, 1.01 卤 0.07, and 1.96 卤 0.19 cm³, respectively, at the time point of 60, 180, and 300 s. In our in vivo experiment, the MCPC could be directly injected into the center of the tumors under the guidance of ultrasound imaging. The formed MCPC was well-restricted within the tumor tissues without leakage, and the tumors were completely ablated by 0.36 g of 10% injectable MCPC after 180 s of induction heating.