Facile Synthesis of Molecularly Imprinted Graphene Quantum Dots for the Determination of Dopamine with Affinity-Adjustable

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• 作者：Xi Zhou ; Anqi Wang ; Chenfei Yu ; Shishan Wu ; Jian Shen
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：June 10, 2015
• 年：2015
• 卷：7
• 期：22
• 页码：11741-11747
• 全文大小：388K
• ISSN：1944-8252

文摘

A facilely prepared fluorescence sensor was developed for dopamine (DA) determination based on polyindole/graphene quantum dots molecularly imprinted polymers (PIn/GQDs@MIPs). The proposed sensor exhibits a high sensitivity with a linear range of 5 脳 10^鈥?0 to 1.2 脳 10^鈥? M and the limit of detection as low as 1 脳 10^鈥?0 M in the determination of DA, which is probably due to the tailor-made imprinted cavities for binding DA thought hydrogen bonds between amine groups of DA and oxygen-containing groups of the novel composite. Furthermore, the prepared sensor can rebind DA in dual-type: a low affinity type (noncovalent interaction is off) and a high affinity type (noncovalent interaction is on), and the rebinding interaction can be adjusted by tuning the pH, which shows a unique potential for adjusting the binding interaction while keeping the specificity, allowing for wider applications.