Synthesis and Self-Assembly of Bundle-Forming α-Helical Peptide–Dendron Hybrids

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• 作者：Jeannette E. Marine ; Shuang Song ; Xiaoli Liang ; Jonathan G. Rudick
• 刊名：Biomacromolecules
• 出版年：2016
• 出版时间：January 11, 2016
• 年：2016
• 卷：17
• 期：1
• 页码：336-344
• 全文大小：608K
• ISSN：1526-4602

文摘

Dendronized helix bundle assemblies combine the sequence diversity and folding properties of proteins with the tailored physical properties of dendrimers. Assembly of peptide–dendron hybrids into α-helical bundles encapsulates the helix bundle motif in a dendritic sheath that will allow the functional, protein-like domain to be transplanted to nonbiological environments. A bioorthogonal graft-to synthetic strategy for preparing helix bundle-forming peptide–dendron hybrids is described herein for hybrids 1a, 1b, and 2. Titration experiments monitored by circular dichroism spectroscopy support our self-assembly model for how the peptide–dendron hybrids self-assemble into α-helical bundles with the dendrons on outside of the bundle.