Bioresorbable Electronic Stent Integrated with Therapeutic Nanoparticles for Endovascular Diseases

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• 作者：Donghee Son ; Jongha Lee ; Dong Jun Lee ; Roozbeh Ghaffari ; Sumin Yun ; Seok Joo Kim ; Ji Eun Lee ; Hye Rim Cho ; Soonho Yoon ; Shixuan Yang ; Seunghyun Lee ; Shutao Qiao ; Daishun Ling ; Sanghun Shin ; Jun-Kyul Song ; Jaemin Kim ; Taeho Kim ; Hakyong Lee ; Jonghoon Kim ; Min Soh ; Nohyun Lee ; Cheol Seong Hwang ; Sangwook Nam ; Nanshu Lu ; Taeghwan Hyeon ; Seung Hong Choi ; Dae-Hyeong Kim
• 刊名：ACS Nano
• 出版年：2015
• 出版时间：June 23, 2015
• 年：2015
• 卷：9
• 期：6
• 页码：5937-5946
• 全文大小：892K
• ISSN：1936-086X

文摘

Implantable endovascular devices such as bare metal, drug eluting, and bioresorbable stents have transformed interventional care by providing continuous structural and mechanical support to many peripheral, neural, and coronary arteries affected by blockage. Although effective in achieving immediate restoration of blood flow, the long-term re-endothelialization and inflammation induced by mechanical stents are difficult to diagnose or treat. Here we present nanomaterial designs and integration strategies for the bioresorbable electronic stent with drug-infused functionalized nanoparticles to enable flow sensing, temperature monitoring, data storage, wireless power/data transmission, inflammation suppression, localized drug delivery, and hyperthermia therapy. In vivo and ex vivo animal experiments as well as in vitro cell studies demonstrate the previously unrecognized potential for bioresorbable electronic implants coupled with bioinert therapeutic nanoparticles in the endovascular system.