Nitric Oxide Inhibitory Dimeric Sesquiterpenoids from Artemisia rupestris

详细信息    查看全文

• 作者：Chen Zhang ; Shu Wang ; Ke-Wu Zeng ; Jun Li ; Daneel Ferreira ; Jordan K. Zjawiony ; Bing-Yu Liu ; Xiao-Yu Guo ; Hong-Wei Jin ; Yong Jiang ; Peng-Fei Tu
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：January 22, 2016
• 年：2016
• 卷：79
• 期：1
• 页码：213-223
• 全文大小：549K
• ISSN：1520-6025

文摘

Twelve new dimeric sesquiterpenoids (1–12) were isolated from the dried whole plants of Artemisia rupestris. Their structures were determined using MS and NMR data, and the absolute configurations were elucidated on the basis of experimental and calculated ECD spectra. Compounds 1–9 are presumably formed via biocatalyzed [2+2] or [4+2] cycloaddition reactions. Stereoselectivity of the [4+2] Diels–Alder reaction dictated the formation of endo-products. The dimeric sesquiterpenoids exhibited moderate inhibition on NO production stimulated by lipopolysaccharide in BV-2 microglial cells, with IC₅₀ values in the range 17.0–71.8 μM.