Palladium-Catalyzed Decarboxylative Acylation of N-Nitrosoanilines with α-Oxocarboxylic Acids

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• 作者：Yinuo Wu ; Lei Sun ; Yunyun Chen ; Qian Zhou ; Jia-Wu Huang ; Hui Miao ; Hai-Bin Luo
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：February 5, 2016
• 年：2016
• 卷：81
• 期：3
• 页码：1244-1250
• 全文大小：454K
• ISSN：1520-6904

文摘

A palladium-catalyzed oxidative C–H bond decarboxylative acylation of N-nitrosoanilines using α-oxocarboxylic acid as the acyl source is described. The catalyst Pd(OAc)₂ and oxidant (NH₄)₂S₂O₈ enabled ortho-acylation of N-nitrosoanilines at room temperature, affording an array of N-nitroso-2-aminobenzophenones in moderate to excellent yields.