Multicomponent Cascade Synthesis of Trifluoroethyl Isoquinolines from Alkynes and Vinyl Azides

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• 作者：Kai Liu ; Shuang Chen ; Xing Guang Li ; Pei Nian Liu
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：January 4, 2016
• 年：2016
• 卷：81
• 期：1
• 页码：265-270
• 全文大小：429K
• ISSN：1520-6904

文摘

A multicomponent cascade reaction is described that provides concise access to the trifluoroethyl isoquinolines using a Rh(III)–Cu(II) bimetallic system and readily available Togni’s reagent. The system tolerates various vinyl azides and internal alkynes. Experimental results suggest that Togni’s reagent might act as a CF₃ radical supplier.