Copper-Mediated Aerobic Oxidative Synthesis of 3-Bromo-imidazo[1,2-a]pyridines with Pyridines and Enamides

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• 作者：Xiaoqiang Zhou ; Hao Yan ; Chaowei Ma ; Yongqin He ; Yamin Li ; Jinhui Cao ; Rulong Yan ; Guosheng Huang
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：January 4, 2016
• 年：2016
• 卷：81
• 期：1
• 页码：25-31
• 全文大小：471K
• ISSN：1520-6904

文摘

A conversion of pyridines and enamides for the synthesis of 3-bromo-imidazo[1,2-a]pyridines was developed by copper-mediated aerobic oxidative coupling in a one-pot manner. This procedure tolerates various functional groups and affords a series of 3-bromo-imidazo[1,2-a]pyridines under mild conditions.