Nickel-Catalyzed Borylation of Aryl- and Benzyltrimethylammonium Salts via C–N Bond Cleavage

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• 作者：Jiefeng Hu ; Heqing Sun ; Wangshui Cai ; Xinghui Pu ; Yemin Zhang ; Zhuangzhi Shi
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：January 4, 2016
• 年：2016
• 卷：81
• 期：1
• 页码：14-24
• 全文大小：677K
• ISSN：1520-6904

文摘

By developing a mild Ni-catalyzed system, a method for direct borylation of sp² and sp³ C–N bonds has been established. The key to this hightly efficient C–N bond borylative cleavage depends on the appropriate choice of the nickel catalyst Ni(COD)₂, ICy·HCl as a ligand, and the use of 2-ethoxyethanol as the cosolvent. This transformation shows good functional group compatibility and can serve as a powerful synthetic tool for gram-scale synthesis and late-stage C–N borylation of complex compounds.