Red-Light-Responsive Supramolecular Valves for Photocontrolled Drug Release from Mesoporous Nanoparticles

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• 作者：Dongsheng Wang ; Si Wu
• 刊名：Langmuir
• 出版年：2016
• 出版时间：January 19, 2016
• 年：2016
• 卷：32
• 期：2
• 页码：632-636
• 全文大小：371K
• ISSN：1520-5827

文摘

Red-light-responsive supramolecular valves constructed by tetra-ortho-methoxy-substituted azobenzene (mAzo) and β-cyclodextrin (β-CD) were used to control drug release from mesoporous silica nanoparticles (MSNs). Doxorubicin (DOX) was used as a model drug and loaded into nanopores of mAzo modified MSNs. β-CD formed supramolecular valves with mAzo by host–guest interaction and closed the nanopores. Red light was able to open the supramolecular valves and induce DOX release even in deep tissue.