Neosartoryadins A and B, Fumiquinazoline Alkaloids from a Mangrove-Derived Fungus Neosartorya udagawae HDN13-313

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• 作者：Guihong Yu ; Guoliang Zhou ; Meilin Zhu ; Wei Wang ; Tianjiao Zhu ; Qianqun Gu ; Dehai Li
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：January 15, 2016
• 年：2016
• 卷：18
• 期：2
• 页码：244-247
• 全文大小：290K
• ISSN：1523-7052

文摘

Neosartoryadins A (1) and B (2), both with a unique 6/6/6/5 quinazoline ring system connected directly to a 6/5/5 imidazoindolone ring, together with three biogenetically related compounds 3–5, were isolated from the endophytic fungus Neosartorya udagawae HDN13-313. The absolute configurations of new compounds 1–4 were established. Compounds 1 and 2 displayed anti-influenza virus A (H1N1) activities with IC₅₀ values of 66 and 58 μM, respectively (ribavirin as positive control, IC₅₀ = 94 μM).