Appropriate Size of Magnetic Nanoparticles for Various Bioapplications in Cancer Diagnostics and Therapy

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• 作者：Xiaomeng Guo ; Zhe Wu ; Wei Li ; Zuhua Wang ; Qingpo Li ; Fenfen Kong ; Hanbo Zhang ; Xiuliang Zhu ; Yiping P. Du ; Yi Jin ; Yongzhong Du ; Jian You
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：February 10, 2016
• 年：2016
• 卷：8
• 期：5
• 页码：3092-3106
• 全文大小：967K
• ISSN：1944-8252

文摘

The development of multifunctional nanoparticles has attracted increasing attention. The versatility of nanoparticles largely depends on their physiochemical properties (especially size). However, the optimized size range may be different for the bioapplications of each function associated with multifunctional nanoparticles. It is important to investigate every optimized size range to ascertain which size enables the best function of the nanoparticles before deciding their final size. In this work, we synthesized a series of monodisperse Fe₃O₄ nanoparticles with identical surface properties ranging in size from 60 to 310 nm and systematically investigated their biobehavior and application. Our data indicate that compared to their large counterparts, small Fe₃O₄ nanoparticles exhibited greater cellular internalization and deeper penetration into multicellular spheroids, thus enabling a higher photothermal ablation efficacy in vitro. Interestingly, larger Fe₃O₄ nanoparticles showed greater accumulation in tumors, thereby inducing more efficient tumor growth inhibition. In addition, 120 nm may be the optimal diameter of Fe₃O₄ nanoparticles for magnetic resonance imaging and photoacoustic tomography in vitro. However, more efficient in vivo imaging mediated by Fe₃O₄ nanoparticles will predominantly depend on their high accumulation. Our work presents a different appropriate size range for each biofunction of Fe₃O₄ nanoparticles, which could be a valuable reference for future nanoparticle design.