A Novel Strategy for Softening Gelatin–Bioactive-Glass Hybrids

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• 作者：Ali Negahi Shirazi ; Ali Fathi ; Francia Garces Suarez ; Yiwei Wang ; Peter K. Maitz ; Fariba Dehghani
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：January 27, 2016
• 年：2016
• 卷：8
• 期：3
• 页码：1676-1686
• 全文大小：656K
• ISSN：1944-8252

文摘

The brittle structure of polymer–bioactive-glass hybrids is a hurdle for their biomedical applications. To address this issue here, we developed a novel method to cease the overcondensation of bioactive-glass by polymer cross-linking. Here, an organosilane-functionalized gelatin methacrylate (GelMA) is covalently bonded to a bioactive-glass during the sol–gel process, and the condensation of silica networks is controlled by photo-cross-linking of GelMA. The physicochemical properties and mechanical strength of these hybrids are tunable by the incorporation of secondary cross-linking agents. These hydrogels display elastic properties with ultimate compression strain above 0.2 mm·mm^–1 and tunable compressive modulus in the range of 42–530 kPa. In addition, these hydrogels are bioactive because they promoted the alkaline phosphatase activity of bone progenitor cells. They are also well-tolerated in the mice subcutaneous model. Therefore, our method is efficient for the prevention of overcondensation and allows preparation of soft bioactive hydrogels from organic–inorganic matrices, suitable for soft and hard tissue regeneration.