Microwave Heating of Poly(N-isopropylacrylamide)-Conjugated Gold Nanoparticles for Temperature-Controlled Display of Concanavalin A

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• 作者：Roshan B. Vasani ; Nayana Janardanan ; Beatriz Prieto-Simón ; Anna Cifuentes-Rius ; Siobhan J. Bradley ; Eli Moore ; Tobias Kraus ; Nicolas H. Voelcker
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：December 23, 2015
• 年：2015
• 卷：7
• 期：50
• 页码：27755-27764
• 全文大小：561K
• ISSN：1944-8252

文摘

We demonstrate microwave-induced heating of gold nanoparticles and nanorods. An appreciably higher and concentration-dependent microwave-induced heating rate was observed with aqueous dispersions of the nanomaterials as opposed to pure water and other controls. Grafted with the thermoresponsive polymer poly(N-isopropylacrylamide), these gold nanomaterials react to microwave-induced heating with a conformational change in the polymer shell, leading to particle aggregation. We subsequently covalently immobilize concanavalin A (Con A) on the thermoresponsive gold nanoparticles. Con A is a bioreceptor commonly used in bacterial sensors because of its affinity for carbohydrates on bacterial cell surfaces. The microwave-induced thermal transitions of the polymer reversibly switch on and off the display of Con A on the particle surface and hence the interactions of the nanomaterials with carbohydrate-functionalized surfaces. This effect was determined using linear sweep voltammetry on a methyl-α-d-mannopyranoside-functionalized electrode.