Orthogonal Approach to Construct Cell-Like Vesicles via Pillar[5]arene-Based Amphiphilic Supramolecular Polymers

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• 作者：Leilei Rui ; Lichao Liu ; Yong Wang ; Yun Gao ; Weian Zhang
• 刊名：ACS Macro Letters
• 出版年：2016
• 出版时间：January 19, 2016
• 年：2016
• 卷：5
• 期：1
• 页码：112-117
• 全文大小：411K
• ISSN：2161-1653

文摘

A reduction-responsive supramolecular diblock copolymer was successfully constructed by the orthogonal assembly of two homopolymers in aqueous solution via pillar[5]arene-based host–guest interactions for the first time. The homopolymers, namely, polystyrene modified with ethyl viologen as the terminal group (PS-EV) and polyethylene glycol bearing pillar[5]arene (PEG-P[5]A), were synthesized via reversible addition–fragmentation chain transfer (RAFT) polymerization and coupling reaction, respectively. The supramolecular diblock copolymer can self-assemble into stable binary cell-like vesicles in aqueous solution, where a spherical micelle as the cell nucleus was embedded in a clear outer vesicle as the cell membrane. The cell-like vesicles can be disassembled into spherical aggregates through addition of reducing agent and further used for encapsulation and controlled release of model molecules.