Synthesis of Chiral β-Amino Nitroalkanes via Rhodium-Catalyzed Asymmetric Hydrogenation

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• 作者：Pan Li ; Ming Zhou ; Qingyang Zhao ; Weilong Wu ; Xinquan Hu ; Xiu-Qin Dong ; Xumu Zhang
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：January 4, 2016
• 年：2016
• 卷：18
• 期：1
• 页码：40-43
• 全文大小：344K
• ISSN：1523-7052

文摘

The asymmetric hydrogenation of β-amino nitroolefins has been successfully achieved by rhodium/bis(phosphine)-thiourea L₁ with excellent enantioselectivities and yields (up to 96% ee, 96% yield, >99% conversion, TON up to 1000) under mild conditions. Chiral β-amino nitroalkane products and their derivatives are versatile intermediates in organic synthesis.