LC–UV-Guided Isolation and Structure Determination of Lancolide E: A Nortriterpenoid with a Tetracyclo[5.4.0.02,4.03,7]undecane-Bridged System from a “Talented” Schisandra Plant

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• 作者：Yi-Ming Shi ; Song-Liang Cai ; Xiao-Nian Li ; Miao Liu ; Shan-Zhai Shang ; Xue Du ; Wei-Lie Xiao ; Jian-Xin Pu ; Han-Dong Sun
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：January 4, 2016
• 年：2016
• 卷：18
• 期：1
• 页码：100-103
• 全文大小：314K
• ISSN：1523-7052

文摘

Lancolide E (1) featuring a complex tetracyclo[5.4.0.0^2,4.0^3,7]undecane-bridged system that is constructed by an eight-, a three-, and two five-membered carbon rings in a sterically congested region was obtained in trace amounts from a “talented” schinortriterpenoid producer Schisandra lancifolia. Its structure was fully characterized by combining 2D NMR spectroscopy, theoretical calculations, and X-ray diffraction analysis. The biogenetic pathway of 1 was proposed to involve a Prins cyclization.