Universal Molecular Scaffold for Facile Construction of Multivalent and Multimodal Imaging Probes

详细信息    查看全文

• 作者：Yongkang Gai ; Guangya Xiang ; Xiang Ma ; Wenqi Hui ; Qin Ouyang ; Lingyi Sun ; Jiule Ding ; Jing Sheng ; Dexing Zeng
• 刊名：Bioconjugate Chemistry
• 出版年：2016
• 出版时间：March 16, 2016
• 年：2016
• 卷：27
• 期：3
• 页码：515-520
• 全文大小：456K
• ISSN：1520-4812

文摘

Multivalent and multimodal imaging probes are rapidly emerging as powerful chemical tools for visualizing various biochemical processes. Herein, we described a bifunctional chelator (BFC)-based scaffold that can be used to construct such promising probes concisely. Compared to other reported similar scaffolds, this new BFC scaffold demonstrated two major advantages: (1) significantly simplified synthesis due to the use of this new BFC that can serve as chelator and linker simultaneously; (2) highly efficient synthesis rendered by using either click chemistry and/or total solid-phase synthesis. In addition, the versatile utility of this molecular scaffold has been demonstrated by constructing several multivalent/multimodal imaging probes labeled with various radioisotopes, and the resulting radiotracers demonstrated substantially improved in vivo performance compared to the two individual monomeric counterparts.