Zwitterionic Cocrystals of Flavonoids and Proline: Solid-State Characterization, Pharmaceutical Properties, and Pharmacokinetic Performance

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• 作者：Hongyan He ; Ying Huang ; Qi Zhang ; Jian-Rong Wang ; Xuefeng Mei
• 刊名：Crystal Growth & Design
• 出版年：2016
• 出版时间：April 6, 2016
• 年：2016
• 卷：16
• 期：4
• 页码：2348-2356
• 全文大小：585K
• ISSN：1528-7505

文摘

We utilized the concepts of crystal engineering to acquire cocrystals of d/l-proline with a variety of flavonoids and further evaluated the impact on solubility and pharmacokinetic of flavonoids. We have synthesized and characterized six d/l-proline cocrystals with flavonoids and their single crystal structures were revealed. The powder dissolution profiles were determined and the pharmacokinetic properties for Kae-l-Pro were analyzed and compared with the corresponding physical mixture. d/l-Proline was found to be a suitable coformer for a variety of structural similar flavonoids. This study may offer an alternative approach for the development of these widely used flavonoids.