Quantification of Short-Chain Chlorinated Paraffins by Deuterodechlorination Combined with Gas Chromatography–Mass Spectrometry

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• 作者：Yuan Gao ; Haijun Zhang ; Lili Zou ; Ping Wu ; Zhengkun Yu ; Xianbo Lu ; Jiping Chen
• 刊名：Environmental Science & Technology
• 出版年：2016
• 出版时间：April 5, 2016
• 年：2016
• 卷：50
• 期：7
• 页码：3746-3753
• 全文大小：387K
• ISSN：1520-5851

文摘

Analysis of short-chain chlorinated paraffins (SCCPs) is extremely difficult because of their complex compositions with thousands of isomers and homologues. A novel analytical method, deuterodechlorination combined with high resolution gas chromatography–high resolution mass spectrometry (HRGC–HRMS), was developed. A protocol is applied in the deuterodechlorination of SCCPs with LiAlD₄, and the formed deuterated n-alkanes of different alkane chains can be distinguished readily from each other on the basis of their retention time and fragment mass ([M]⁺) by HRGC–HRMS. An internal standard quantification of individual SCCP congeners was achieved, in which branched C₁₀-CPs and branched C₁₂-CPs were used as the extraction and reaction internal standards, respectively. A maximum factor of 1.26 of the target SCCP concentrations were determined by this method, and the relative standard deviations for quantification of total SCCPs were within 10%. This method was applied to determine the congener compositions of SCCPs in commercial chlorinated paraffins and environmental and biota samples after method validation. Low-chlorinated SCCP congeners (Cl_1–4) were found to account for 32.4%–62.4% of the total SCCPs. The present method provides an attractive perspective for further studies on the toxicological and environmental characteristics of SCCPs.