Prevention of Obesity and Type 2 Diabetes with Aged Citrus Peel (Chenpi) Extract

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• 作者：Jingjing Guo ; Hanlin Tao ; Yong Cao ; Chi-Tang Ho ; Shengkang Jin ; Qingrong Huang
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2016
• 出版时间：March 16, 2016
• 年：2016
• 卷：64
• 期：10
• 页码：2053-2061
• 全文大小：566K
• ISSN：1520-5118

文摘

Chenpi is the dry peel of the plant Citrus reticulata Blanco after an aging processing. It has been used as an antidigestive and anti-inflammatory traditional medicine, as well as culinary seasoning and dietary supplement, in China. However, its efficacy and underlying scientific mechanism have not been sufficiently investigated. Chenpi is uniquely enriched with a high content of 5-demethylated polymethoxyflavones (5-OH PMFs). The effect of chenpi extract on improving metabolic features was examined using high-fat diet (HFD)-induced obesity/diabetes mouse model. Oral administration of 0.25 and 0.5% chenpi extract in food over 15 weeks markedly prevented HFD-induced obesity, hepatic steatosis, and diabetic symptoms. The beneficial effect is associated with 5′-adenosine monophosphate-activated protein kinase (AMPK) activation in adipose tissue. Our results indicate that 5-OH PMFs-enriched chenpi extract is effective in preventing obesity and type 2 diabetes, and its effect might be related to improvement in lipid metabolism associated with activation of the AMPK pathway.