Erinacine S, a Rare Sesterterpene from the Mycelia of Hericium erinaceus

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• 作者：Chien-Chih Chen ; Tsai-Teng Tzeng ; Chin-Chu Chen ; Ching-Li Ni ; Li-Ya Lee ; Wan-Ping Chen ; Young-Ji Shiao ; Chien-Chang Shen
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：February 26, 2016
• 年：2016
• 卷：79
• 期：2
• 页码：438-441
• 全文大小：259K
• ISSN：1520-6025

文摘

A new sesterterpene, erinacine S, and one cyathane diterpene xyloside, erinacine A, were isolated from the ethanol extract of the mycelia of Hericium erinaceus. Their structures were elucidated by spectroscopic and X-ray analysis. A 30-day oral course of erinacines A and S attenuated Aβ plaque burden in the brains of 5-month-old female APP/PS1 transgenic mice. Moreover, erinacines A and S significantly increased the level of insulin-degrading enzyme in cerebral cortex.