Dysiherbols A–C and Dysideanone E, Cytotoxic and NF-κB Inhibitory Tetracyclic Meroterpenes from a Dysidea sp. Marine Sponge

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• 作者：Wei-Hua Jiao ; Guo-Hua Shi ; Ting-Ting Xu ; Guo-Dong Chen ; Bin-Bin Gu ; Zhuo Wang ; Shuang Peng ; Shu-Ping Wang ; Jia Li ; Bing-Nan Han ; Wei Zhang ; Hou-Wen Lin
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：February 26, 2016
• 年：2016
• 卷：79
• 期：2
• 页码：406-411
• 全文大小：364K
• ISSN：1520-6025

文摘

Four new tetracyclic meroterpnes, dysiherbols A–C (1–3) and dysideanone E (4), were isolated from a Dysidea sp. marine sponge collected from the South China Sea. Their complete structures and absolute configurations were unambiguously determined by a combination of NMR spectroscopic data, ECD calculations, and single-crystal X-ray diffraction analysis. Within the sesquiterpene quinol structures, dysiherbols A–C possess an intriguing 6/6/5/6-fused tetracyclic carbon skeleton. The NF-κB inhibitory and cytotoxic activity evaluation disclosed that dysiherbol A (1) showed potent activity with respective IC₅₀ values of 0.49 and 0.58 μM, which were about 10-fold and 20-fold more potent than those of dysiherbols B (2) and C (3), which feature hydroxy and ketone carbonyl groups at the C-3 position.