Bioactive Iridoid Glycosides from the Whole Plants of Rehmannia chingii

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• 作者：Yan-Fei Liu ; Guo-Ru Shi ; Xin Wang ; Chun-Lei Zhang ; Yan Wang ; Ruo-Yun Chen ; De-Quan Yu
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：February 26, 2016
• 年：2016
• 卷：79
• 期：2
• 页码：428-433
• 全文大小：270K
• ISSN：1520-6025

文摘

Nine new iridoid glycosides, rehmachingiiosides A–I (1–9), together with 16 known analogues, were isolated from the whole plants of Rehmannia chingii. The structures of compounds 1–9 were elucidated on the basis of spectroscopic data analysis and from chemical evidence. Furthermore, in two vitro assays, compounds 5 and 10 showed an inhibitory effect on LPS-induced NO production with IC₅₀ values of 2.5 and 7.3 μM, and compounds 4, 6, and 10–12 (when evaluated at 10 μM) exhibited evidence of hepatoprotective effects against APAP-induced HepG2 cell damage.