Optically Monitoring Mineralization and Demineralization on Photoluminescent Bioactive Nanofibers

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• 作者：Xiang Li ; Yangyang Li ; Xiaoyi Chen ; Binbin Li ; Bo Gao ; Zhaohui Ren ; Gaorong Han ; Chuanbin Mao
• 刊名：Langmuir
• 出版年：2016
• 出版时间：April 5, 2016
• 年：2016
• 卷：32
• 期：13
• 页码：3226-3233
• 全文大小：573K
• ISSN：1520-5827

文摘

Bone regeneration and scaffold degradation do not usually follow the same rate, representing a daunting challenge in bone repair. Toward this end, we propose to use an external field such as light (in particular, a tissue-penetrating near-infrared light) to precisely monitor the degradation of the mineralized scaffold (demineralization) and the formation of apatite mineral (mineralization). Herein, CaTiO₃:Yb³⁺,Er³⁺@bioactive glass (CaTiO₃:Yb³⁺,Er³⁺@BG) nanofibers with upconversion (UC) photoluminescence (PL) were synthesized. Such nanofibers are biocompatible and can emit green and red light under 980 nm excitation. The UC PL intensity is quenched during the bone-like apatite formation on the surface of the nanofibers in simulated body fluid; more mineral formation on the nanofibers induces more rapid optical quenching of the UC PL. Furthermore, the quenched UC PL can recover back to its original magnitude when the apatite on the nanofibers is degraded. Our work suggests that it is possible to optically monitor the apatite mineralization and demineralization on the surface of nanofibers used in bone repair.