A Synthesis of 1H-Indazoles via a Cu(OAc)2-Catalyzed N–N Bond Formation

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• 作者：Cheng-yi Chen ; Guangrong Tang ; Fengxian He ; Zhaobin Wang ; Hailin Jing ; Roger Faessler
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：April 1, 2016
• 年：2016
• 卷：18
• 期：7
• 页码：1690-1693
• 全文大小：383K
• ISSN：1523-7052

文摘

A facile synthesis of 1H-indazoles featuring a Cu(OAc)₂-catalyzed N–N bond formation using oxygen as the terminal oxidant is described. The reaction of readily available 2-aminobenzonitriles with various organometallic reagents led to o-aminoaryl N–H ketimine species. The subsequent Cu(OAc)₂-catalyzed N–N bond formation in DMSO under oxygen afforded a wide variety of 1H-indazoles in good to excellent yields.