Spirocyclic Sultam and Heterobiaryl Synthesis through Rh-Catalyzed Cross-Dehydrogenative Coupling of N-Sulfonyl Ketimines and Thiophenes or Furans

详细信息    查看全文

• 作者：Shu-Tao Mei ; Hong-Wen Liang ; Bin Teng ; Nan-Jin Wang ; Li Shuai ; Yi Yuan ; Ying-Chun Chen ; Ye Wei
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：March 4, 2016
• 年：2016
• 卷：18
• 期：5
• 页码：1088-1091
• 全文大小：412K
• ISSN：1523-7052

文摘

A useful approach is developed for the synthesis of various structurally interesting spirocyclic sultams and heterobiaryls using a cross-dehydrogenative coupling strategy that features high atom and step economy. This method employs [Cp*RhCl₂]₂ as a catalyst and N-sulfonylimine, a weak coordinating group, as an efficient directing group to assist C–H activation. A number of the coupled products were converted into interesting molecules through further synthetic transformations.