Continuous-Flow Process for Selective Mononitration of 1-Methyl-4-(methylsulfonyl)benzene

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• 作者：Zhiqun Yu ; Pengcheng Zhou ; Jiming Liu ; Wenzuo Wang ; Chuanming Yu ; Weike Su
• 刊名：Organic Process Research & Development
• 出版年：2016
• 出版时间：February 19, 2016
• 年：2016
• 卷：20
• 期：2
• 页码：199-203
• 全文大小：286K
• ISSN：1520-586X

文摘

An expeditious process for selective nitration of 1-methyl-4-(methylsulfonyl)benzene in a continuous-flow reactor in 98% yield is described. The continuous-flow mononitration ran well in adiabatic condition with 80 wt% sulfuric acid, and residence time was reduced to 5 s. The short residence time can significantly reduce byproducts. Dinitration was also studied for optimization of the mononitration. The spent acid could be reused for several times after concentration in a vacuum.