Linking of Alcohols with Vinyl Azides

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• 作者：Yi-Feng Wang ; Ming Hu ; Hirohito Hayashi ; Bengang Xing ; Shunsuke Chiba
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：March 4, 2016
• 年：2016
• 卷：18
• 期：5
• 页码：992-995
• 全文大小：428K
• ISSN：1523-7052

文摘

A protocol to link alcohols with vinyl azides has been established through fluoro- or bromo-alkoxylation of vinyl azides to provide α-alkoxy-β-haloalkyl azides. A series of primary and secondary alcohols including natural products and their derivatives such as sugars and steroids were successfully anchored with vinyl azides. The as-prepared cyanine dye linked testosterones were capable of rapid cell membrane imaging in real time.