Synthesis of 5,6-Dihydropyrazolo[5,1-a]isoquinolines through Indium(III)-Promoted Halocyclizations of N-Propargylic Sulfonylhydrazones

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• 作者：Ren-Hao Li ; Cheng-Ke Ding ; Ya-Nan Jiang ; Zong-Cang Ding ; Xiao-Ming An ; Hai-Tao Tang ; Qi-Wei Jing ; Zhuang-Ping Zhan
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：April 1, 2016
• 年：2016
• 卷：18
• 期：7
• 页码：1666-1669
• 全文大小：329K
• ISSN：1523-7052

文摘

A novel method for the preparation of 5,6-dihydropyrazolo[5,1-a]isoquinoline via indium(III)-promoted halocyclizations of N-propargylic sulfonylhydrazones has been developed. The pyrazole and 3,4-dihydroisoquinoline moieties were synchronously formed via a cascade cyclization reaction using easily assembled open-chain compounds. The pyrazole and 3,4-dihydroisoquinoline moieties were formed via a cascade cyclization reaction using easily assembled open-chain compounds.