Sericin/Dextran Injectable Hydrogel as an Optically Trackable Drug Delivery System for Malignant Melanoma Treatment

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• 作者：Jia Liu ; Chao Qi ; Kaixiong Tao ; Jinxiang Zhang ; Jian Zhang ; Luming Xu ; Xulin Jiang ; Yunti Zhang ; Lei Huang ; Qilin Li ; Hongjian Xie ; Jinbo Gao ; Xiaoming Shuai ; Guobin Wang ; Zheng Wang ; Lin Wang
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：March 16, 2016
• 年：2016
• 卷：8
• 期：10
• 页码：6411-6422
• 全文大小：767K
• ISSN：1944-8252

文摘

Severe side effects of cancer chemotherapy prompt developing better drug delivery systems. Injectable hydrogels are an effective site-target system. For most of injectable hydrogels, once delivered in vivo, some properties including drug release and degradation, which are critical to chemotherapeutic effects and safety, are challenging to monitor. Developing a drug delivery system for effective cancer therapy with in vivo real-time noninvasive trackability is highly desired. Although fluorescence dyes are used for imaging hydrogels, the cytotoxicity limits their applications. By using sericin, a natural photoluminescent protein from silk, we successfully synthesized a hydrazone cross-linked sericin/dextran injectable hydrogel. This hydrogel is biodegradable and biocompatible. It achieves efficient drug loading and controlled release of both macromolecular and small molecular drugs. Notably, sericin’s photoluminescence from this hydrogel is directly and stably correlated with its degradation, enabling long-term in vivo imaging and real-time monitoring of the remaining drug. The hydrogel loaded with Doxorubicin significantly suppresses tumor growth. Together, the work demonstrates the efficacy of this drug delivery system, and the in vivo effectiveness of this sericin-based optical monitoring strategy, providing a potential approach for improving hydrogel design toward optimal efficiency and safety of chemotherapies, which may be widely applicable to other drug delivery systems.