Potassium Thioacids Mediated Selective Amide and Peptide Constructions Enabled by Visible Light Photoredox Catalysis

详细信息    查看全文

• 作者：Hongxin Liu ; Liyun Zhao ; Yunfei Yuan ; Zhifang Xu ; Kai Chen ; Shengxiang Qiu ; Haibo Tan
• 刊名：ACS Catalysis
• 出版年：2016
• 出版时间：March 4, 2016
• 年：2016
• 卷：6
• 期：3
• 页码：1732-1736
• 全文大小：402K
• ISSN：2155-5435

文摘

A remarkable visible-light-promoted photoredox catalytic methodology involved with amines and eco-friendly potassium thioacids for amide formation was uncovered. This approach can mimic the natural coenzyme acetyl-CoA to selectively acylate amines without affecting other functional groups such as alcohols, phenols, esters, among others. The developed strategy may hold great potential for a comprehensive display of biologically interesting peptide synthesis and amino acid modification through a diacyl disulfide intermediate.