Self-Healing Spongy Coating for Drug “Cocktail‿Delivery

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• 作者：Xia-chao Chen ; Ke-feng Ren ; Wen-xi Lei ; Jia-hui Zhang ; M. Cristina L. Martins ; Mário A. Barbosa ; Jian Ji
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：February 24, 2016
• 年：2016
• 卷：8
• 期：7
• 页码：4309-4313
• 全文大小：347K
• ISSN：1944-8252

文摘

Optimized ratio in the codelivery of therapeutics is of crucial importance to promote the synergism rather than the antagonistic effects. In this study, a self-healing spongy coating was described to facilitate the surface-mediated delivery of drug “cocktails” proportionally. The formation of spongy structures within the coating was achieved by acidic treatment and freeze-drying. Various drug combinations can be readily integrated through wicking method and subsequent micropore self-healing. The ratio of drug loading can be precisely regulated by the composition of loading solution and the embedded drugs were released in proportion according to the initial ratio of drug combination.