Chloroquine-Containing HPMA Copolymers as Polymeric Inhibitors of Cancer Cell Migration Mediated by the CXCR4/SDF-1 Chemokine Axis

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• 作者：Fei Yu ; Ying Xie ; Yan Wang ; Zheng-Hong Peng ; Jing Li ; David Oupický
• 刊名：ACS Macro Letters
• 出版年：2016
• 出版时间：March 15, 2016
• 年：2016
• 卷：5
• 期：3
• 页码：342-345
• 全文大小：302K
• ISSN：2161-1653

文摘

Chloroquine-containing HPMA copolymers (pCQs) were synthesized for the first time by copolymerization of methacryloylated hydroxychloroquine and HPMA. The copolymers showed lower cytotoxicity when compared with hydroxychloroquine. Treatment of cancer cells with pCQ resulted in decreased surface expression of chemokine receptor CXCR4. The pCQ copolymers showed effective inhibition of CXCR4/SDF1-mediated cancer cell migration that was fully comparable with a commercial small-molecule CXCR4 antagonist AMD3100. The reported pCQ represent unique and simple polymeric drugs with potential use as part of a combination antimetastatic therapies.