Nanoscale Metal–Organic Particles with Rapid Clearance for Magnetic Resonance Imaging-Guided Photothermal Therapy

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• 作者：Yu Yang ; Jingjing Liu ; Chao Liang ; Liangzhu Feng ; Tingting Fu ; Ziliang Dong ; Yu Chao ; Yonggang Li ; Guang Lu ; Meiwan Chen ; Zhuang Liu
• 刊名：ACS Nano
• 出版年：2016
• 出版时间：February 23, 2016
• 年：2016
• 卷：10
• 期：2
• 页码：2774-2781
• 全文大小：546K
• ISSN：1936-086X

文摘

Nanoscale metal–organic particles (NMOPs) are constructed from metal ions and organic bridging ligands via the self-assembly process. Herein, we fabricate NMOPs composed of Mn²⁺ and a near-infrared (NIR) dye, IR825, obtaining Mn-IR825 NMOPs, which are then coated with a shell of polydopamine (PDA) and further functionalized with polyethylene glycol (PEG). While Mn²⁺ in such Mn-IR825@PDA–PEG NMOPs offers strong contrast in T₁-weighted magnetic resonance (MR) imaging, IR825 with strong NIR optical absorbance shows efficient photothermal conversion with great photostability in the NMOP structure. Upon intravenous injection, Mn-IR825@PDA–PEG shows efficient tumor homing together with rapid renal excretion behaviors, as revealed by MR imaging and confirmed by biodistribution measurement. Notably, when irradiated with an 808 nm laser, tumors on mice with Mn-IR825@PDA–PEG injection are completely eliminated without recurrence within 60 days, demonstrating the high efficacy of photothermal therapy with this agent. This study demonstrates the use of NMOPs as a potential photothermal agent, which features excellent tumor-targeted imaging and therapeutic functions, together with rapid renal excretion behavior, the latter of which would be particularly important for future clinical translation of nanomedicine.